What is Tianeptine? Is it effective?


TIANEPTINE: WHAT IS TIANEPTINE? There are a number of drugs being tested and already on the marker that qualifies as nootropics, which are presented as “Smart Drugs”. Smart Drugs are believed to be low-risk and work to improve, enhance, or repair damage done to the brain via injury or disease. Most of the nootropics commonly discussed fall under the heading of Racetam, yet there are many that do not. Tianeptine is a nootropic, but it is classified as an antidepressant selective serotonin re-uptake enhancer (SSRE). Tianeptine is generally prescribed in doses broken up into individual doses of approximately 12 mg each, in the treatment of severe depression, anxiety disorders, bipolar disorder, and other “adjustment disorders”. In clinical trials, it has been determined that Tianeptine is as efficient as more common antidepressants, like amitriptyline and clomipramine. In addition, their effectiveness seems to require a smaller dose than the traditional antidepressants, as well (Wagstaff & et. al, 2001). HOW DOES TIANEPTINE WORK? What makes Tianeptine so effective is that it reduces stress on the brain, both physical and mental. Tianeptine causes stress-induced alterations morphology and synaptic plasticity. As it alleviates stress, it also improved learning, brain cognition and memory, two things often diminished by serious depressive conditions. (Zoldaz & et. al, 2010). Like many drugs, there are still studies and concerns that the efficiency and effectiveness of Tianeptine as a whole is difficult to ascertain. After all, Tianeptine, like many drugs, can have a vastly distinct effect on some people and entirely different one on others. More studies are needed to determine if there is a universal dose or regiment that can produce absolute results. TIANEPTINE SIDE EFFECTS Unlike many antidepressants, Tianeptine has few negative side effects; Tianeptine is showing promise as an alternative to traditional antidepressants and their addictive nature and long-list of side effects (Gassaway & et. al., 2014). While the majority of antidepressant users do not abuse or misuse the medication, they are prescribed, that does not speak to the rest of the public. Antidepressants are a very popular and dangerous recreational activity. For people who do not need them, the taking of such drugs can come with many negative side effects and potential addictive properties (Evans & Sullivan, 2014). Tianeptine may be a much safer alternative to many of the antidepressants on the market today. The listing of side effects that are associated with are minor and tolerable, they include drowsiness, dry-mouth, insomnia, dizziness, constipation, bouts of low blood pressure, and some patients describe unusually vivid dreams. BENEFITS AND EFFECTS OF TIANEPTINE This multitasking drug has a great deal of potential in medicine, therapeutic psychological and counseling goals, and provides a potential enhancement to brain function. Finding way to improve the mental state of those suffering from debilitating disease and emotional conditions that are both effective, efficient, and has a limited amount of serious side effects is worthwhile. Granted, it is necessary that experts and researchers continue their studies to determine if there are any deleterious effects or unforeseen consequences that have yet to be discovered. However, as with all drugs, regardless of the side effects, should not be taken outside of a professional’s care or for recreational purposes. Even so, it would appear that the future of Tianeptine is to be a positive one, and with further research and study may become one of the mainstay medications prescribed to address depression in more patients who require them. ADDITIONAL INFORMATION ON TIANEPTINE Tianeptine was discovered in the 1960s by the French Society of Medical Research. This nootropic is available as a prescription for depression in some countries under the trade names of Coaxil, Stablon, Tianeurax and Tatinol. Despite sharing structural similarities with tricyclic antidepressants, Tianeptine lacks several drawbacks that SSRIs carry and has more positive benefits beyond just being an antidepressant. Tianeptine is a water-soluble nootropic used for its antidepressant and antioxylic qualities. Tianeptine is an SSRE (selective serotonin reuptake enhancer) in contrast to being an SSRI like many anti-depression and anti-anxiety medication. It is suspected that Tianeptine due to it being an SSRE lacks adverse side effects such as cardiovascular activity, anticholinergic activities, and being a sedative like most SSRIs. However similar to SSRIs, Tianeptine onset-of-action takes approximately between 2 to 6 weeks but some benefits have been reported to be observable within the first week of use. Tianeptine is purported from one study to have plausible benefits in regard to memory and learning abilities through the increase of elastic memory in non-stressed induced patients. By reducing the effects of serotonin in the lymbic system as well as the pre-frontal cortex Tianeptine causes mood elevation compared to the mood depreciating effects common with SSRIs. In one study, Tianeptine was found to be also be a logical treatment for Treatment Resistant Depression (TRD) in conjuncture with or without medication as well as having believable anticonvulsant and analgesic qualities. One study conducted with a placebo (saline), and Tianeptine showed that in stress induced mice the Tianeptine showed an improvement in regard to specific areas of the brain. This shows that under a state of stress, Tianeptine has plausible neuro defensive qualities in comparison to a Pharmacol Biochem Behav. 2012 Dec;103(2):395-402.Tianeptine exerts neuro protective effects in the brain tissue of rats exposed to the chronic stress model. Tianeptine not only has useful benefits in regard to helping treat depression and anxiety, which are currently believed to be due to its explicit effects stimulating both the AMPA and NMDA, but is believed to have memory protective properties. The article covers a wide area on how this nootropic is as effective as SSRIs in regards for depression, and that due to its ability to block negative effects of stress on hippocampus dominant learning and memory. Curr Neuropharmacol. 2008 December; 6(4): 311a 321. Tianeptine: An Antidepressant with Memory-Protective Properties. TIANEPTINE DOSAGE The recommended dosage of Tianeptine capsules is usually 12-36 mg per day, taken as 12mg individual dosages, one in the morning and one in the afternoon and a final in the evening time. This substance is sold in capsule, tablet and powder form. DOES TIANEPTINE WORK? Tianeptine has several potential mechanisms of action from the actions on serotonin receptors as well as having possible neuro-protective activities. It also aids in reducing negative effects caused by stress in areas of the brain that are used for memorization and learning properties. There are still many variables though that have to be looked at with improving cognitive abilities and improving overall mood. As a result, it is very hard to determine just how effective Tianeptine would be for a specific person. It all comes down to their own needs and current cognitive ability, mood, and lifestyle choices.

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